|
Synthesis new liquid electrodes and use to determination Diclofenec sodium based on a molecularly imprinted polymer
|
|
| Author:
|
MOHAMMED MADLOOL AL-NISANI, MOHAMMED ELMUBARAK OSMAN, YEHYA KAMAL AL-BAYATI
|
| Abstract:
|
Three Liquid electrodes from Diclofenec sodium (DFS) imprinted polymer were synthesis based on precipitation polymerization mechanism. The molecularly imprinted polymers (MIP) and non-imprinted polymers (NIP) were synthesized by using DFS as a template. and uses 1-Vinylimidazole (VIZ) acrylamide (AA) and Styrene as monomers, Ethylene glycol dimethyl acrylate(EGDMA) cross-linkers and benzoyl peroxide (BPO) as an initiator. Three molecularly imprinted membranes were synthesis using Tris (2-ethylhexyl) phosphate (TEHP) Di butyl phthalate (DBPH) and Dioctyl phthalate (DOPH) plasticizers in PVC matrix. The limit of detection and slopes of liquid electrodes obtained from the calibration curves ranged. 7×10-6, – 2.9 ×10-7and4.5×10-7, M,17.87,19.415and19.168 mV/decade respectively and the response time was about 60 seconds. The liquid electrodes were filled with the drug's standard 10-1 M solution, and stable response was observed for a pH range from 1 to 9.5 and good selectivity for more than several species. The new synthesis electrodes were successfully utilized in the pharmaceutical sample to determine DFS without any time-consuming pretreatment steps.
|
| Keyword:
|
Molecularly imprinted electrodes, Diclofenecsodium, liquid electrodes, Styrene, acrylamide monomers.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.SP1.197
|
| Download:
|
Request For Article
|
|
|