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In-silico evidences of serotonin transporter protein (SERT) on antidepressant flavonoids
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| Author:
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JASMIN PANDA, SOVAN PATTANAIK, PRASANNA PRADHAN, ABHISEK PAL, DURGA MADHAB KAR
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| Abstract:
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The present investigation focused on a series of antioxidant flavonoids previously claimed for its various physiological and biochemical functions including antipsychotic actions. Eleven flavonoid compounds were screened for their binding affinity with serotonin transporter (SERT) by molecular docking using AUTODOCK Tools-1.5.6 & 4.2. The new SERT protein was designed and validated through homology modeling by using the SWISS-Model server. Binding interaction of Tamarixetin and Ombuin flavonoids exhibited appreciable conformation among other flavonoids with SERT protein which could be comparable with fluoxetine and serotonin. This study also helps to predict the delayed action of natural ligands towards SERT protein resulting in the finding of distinguishing binding energy. These results and pose interaction, suggest that natural antioxidant flavonoids could potentially act due to its action against the SERT system as like as selective serotonin reuptake inhibitors (SSRI).
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| Keyword:
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flavonoid, SERT, AUTODOCK Tools-1.5.6, SWISS-Model, SSRI
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.171
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| Download:
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