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Imbalance in the oxidative stress system – antioxidant protection in patients with chronic pyelonephritis depending on the course of the disease
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| Author:
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OLGA A. EFREMOVA, LYUDMILA A. KAMYSHNIKOVA, SULEIMAN E. VEYSALOV, MARIA S. SVIRIDOVA, NATALYA I. OBOLONKOVA, ANDREI A. MASLENNIKOV, MARYAM WURAOLA
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| Abstract:
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Objectives: - assessment of the imbalance in the system of oxidative stress – antioxidant protection in patients with chronic pyelonephritis (CP) depending on the course of the disease.
Materials and Methods: patients were divided into three groups: the first group (29 patients) consisted of patients with recurrent course of CP, exacerbations of 3 or more times per year (CPr); the second (34 patients) – patients with active phase of pyelonephritis (CPc), having comorbid cardiovascular pathology (stable coronary heart disease (CHD) with heart failure I-II FC); the third control group (35 patients) consisted of patients with an active phase of the disease (CP) who has had a history of pyelonephritis for at least 5 years, rare exacerbations – not more than once in a year. Results: it was established that patients with a recurring course of pyelonephritis (CPr), an increase in oxidative stress (OS) activity and an increase in malondialdehyde (MDA) production are characteristic against the background of a decrease in antioxidant protection parameters (AOP), moreover, the recurrent course of CP produced a more significant effect on patients: for patients with CPr (with 3 or more relapses per year) were characterized by lower superoxide dismutase (SOD) and catalase (Cat) values compared with similar indicators in the group of patients with chronic pyelonephritis without relapse. For patients with CP and comorbid pathology, a disturbance in the oxidative balance was also characteristic, which was manifested by an increase in the average levels of MDA and diene conjugate (DC) in the blood serum (by 12.3% and 9.1%, respectively, p<0.001) against the background of a decrease average values Cat content (by 18.2%, p<0.001) and a pronounced tendency for a decrease in SOD. Conclusion: in comparison with the recurrent course of pyelonephritis (CPr) in patients with comorbid pathology, oxidative stress was more pronounced, which was manifested in a significantly greater increase in lipid peroxidation and a decrease in AOP factors. Perhaps increased free radical activity is one of the factors involved in the pathogenesis of the inflammatory syndrome in patients with chronic pyelonephritis and comorbid pathology.
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| Keyword:
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pyelonephritis, free radical activity, comorbid pathology, oxidative stress, lipid peroxidation, antioxidant system.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.161
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