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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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An Efficacy of Autologous Serum Therapy In Chronic Idiopathic Urticaria

Author: KIRUBA.D , SUNDARAMORTHY SRINIVASAN
Abstract: Chronic idiopathic urticaria (CIU) is a very communal distressing allergicskin complaint. CIU not responsive to antihistamine and other oral drugs is difficult to treat and is a therapeutic challenge to a dermatologist. This work focuses to appraise the effectiveness of autologous serum therapy (AST) in patients with chronic idiopathic urticaria and to compare Autologous serum skin test positive and negative patients response to autologous serum therapy. Sixty patients with chronic idiopathic urticaria not responding to other modalityof treatment were selected for the study. All care was taken to follow strictly the inclusion and exclusion criteria. ASST was done to all patients who were selected for the study. Thirty patients were given autologous serum and remaining thirty were given injection normal saline (control group) weekly for nine weeks and advised for atleast two followup visits at 20 week. Assessed using urticaria total severity score (TSS), among 60 pts 25% were ASSTpositive. TSS presentedimportant reduction in AST group than the control group and the response between ASST positive and negative patients was not statistically significant. Autologous serum therapy is operative in the treatment of CIU. ASSTpositive as well as negative patients responded to AST but when compared ASST positive patients response was earlier and better than negative patient. AST should be considered seriously for all treatment refractory cases of CIU.
Keyword: Autologous,Chronic idiopathic urticaria,Autologous serum skin test,urticaria total severity score,autologous serum therapy,chronic idiopathic urticaria
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