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Role Of Cytokines In Inflammation
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| Author:
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AKANSHA KISHEN, DR. N. P. MURALIDHARAN
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| Abstract:
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Inflammation is a beneficial response which is being activated to restore the tissue injury and various pathogenic agents. It constitutes several pathological and physiological processes. Inflammation also results in the recruitment of various leukocytes and plasma proteins to the affected tissue site. Tissue stress or malfunction in it similarly induces an adaptive response, this response is termed as para-inflammation. Cytokines are considered to be redundant secreted proteins that will regulate growth differentiation and activation functions which will determine the nature of immune responses at the time of inflammation. These cytokines will act as inflammatory mediators at the site of inflammation. Most of the cytokines are considered to be multi-functional. They are the pleiotropic molecules that elicit their effect both locally as well as systemically in case of autocrine or else paracrine. The cytokines are involved in extensive networks that are involved in a synergistic as well as antagonist interactions thus exhibiting both position and negative regulatory effects on various target cells. There are many different types of cytokines used in clinical settings. This includes various chemokines, interferons, lymphokines, and also tumor necrosis factors. The main motives of these cytokines are to regulate the immune responses in the body. On the other hand, inflammation can be categorized into two main types- acute inflammation and chronic inflammation. In this update, we will be dealing with the role of cytokines in case of inflammations. the main aim of the study is to investigate the role of cytokines in case of different inflammation
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| Keyword:
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inflammation; cytokines; chemokines; immune responses; interferons
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.019
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| Download:
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