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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Influence of Radiation on Viral Mutations

Author: TITUS LALITH ANTONY, N.P. MURALIDHARAN, JOTHI PRIYA. A
Abstract: An adjustment in the nucleotide arrangement of the genome of a lifeform, infection or extrachromal DNA is called as mutation. The genomes can be either RNA or DNA. Mutation results from mistakes during DNA replication, mitosis. Variation in the genes of viruses can be produced by significant changes in the genome structure and association can happen by hereditary recombination. RNA infections are intrinsically hypervariable as RNA polymerases which secrete the viral genome and mistake altering capacities that happen in cell RNA polymerases. Mutation is a definitive wellspring of all hereditary variety, giving the crude material on which developmental powers, for example, natural selection can act. Mutation rates fluctuate considerably across species, and the developmental powers that for the most part decide mutation are the subject of continuous examination. Mutation rate is a parameter for understanding viral advancement and has a significant down to earth suggestion. The genomes of RNA infections depend on RNA as opposed to DNA. Exposure to UV radiation is perceived to cell mediated immunity and therefore could unfavorably influence viral contamination. From a genetic point of view, infections can be ordered by whether the genome involves RNA or DNA. RNA infections are intrinsically hypervariable as RNA polymerases, which recreate the viral genome, need editing and mistake altering capacities that happen in cell DNA polymerases. The aim and necessity of this study is to gain knowledge about the radiation induced mutation of viruses.
Keyword: Mutation; Viruses; Radiation; DNA; RNA; Genomic change.
DOI: https://doi.org/10.31838/ijpr/2020.SP1.009
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