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Antiviral Activity of Phyllanthus
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| Author:
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JAI REXLIN REXLIN.P.E, N.P. MURALIDHARAN, ANITHA ROY
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| Abstract:
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Phyllanthus is a flowering plant used in Ayurvedic Healing for treating various harmful diseases. It is an Hepatoprotective agent and is used to treat various diseases of the Urogenital system and it also possesses Antiseptic properties. Pharmacological uses of Phyllanthus are Intestinal infections, Diabetes, Hepatitis, Dysentery, Skin infections, Gonorrhea, Heavy menstrual bleeding, Expectorant, etc. Phyllanthus extract contains Corilagin that can possibly act against Human Enterovirus 71 and Coxsackie Virus. Phyllanthus urinaria loses detectable Hepatitis B e antigen from serum. The Phyllanthus amarus plant suppresses HBV mRNA transcription in vitro and exhibits therapeutic potential in chronic HBV carriers. Phyllanthus urinaria attacks the Hbe Antigen in serum. The aqueous extract of Phyllanthus urinaria inhibited the viral entry, thereby down regulating the viral gB, gD and VP16 which are essential for viral attachment and entry, It inhibits the manipulation of the host actin-cytoskeleton dynamics by the virus and it also prevents the manipulation of the host proteins by the virus.. Phyllanthus amarus derived preparations block interaction HIV-1 gp120 and the Polyphenol Extract and Gallic Acid of Lipid Lowering activity of Phyllanthus niruri is mediated through inhibition of hepatic cholesterol biosynthesis, increased faecal bile acids excretion and enhanced plasma lecithin: cholesterol acyltransferase activity.The standardized methanol extracts of P. amarus and P. urinaria and their biomarkers phyllanthin and hypophyllanthin were able to modulate the innate immune response of phagocytes especially on the chemotactic migration of phagocytes, and on the release of ROS. Among the extracts, P. amarus consistently showed strong inhibition at different steps of the phagocytosis, emphasizing its potential as an immunomodulating product. Hence this is about the conventional way of treating various viral diseases with Phyllanthus and its species.
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| Keyword:
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Phyllanthus, Human Enterovirus 71, Coxsackie virus, Hepatitis virus, HSV, HIV, Immunomodulation.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.002
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| Download:
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