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Evaluation of penile erectile function changes by assessing the nitrate oxidase expression in rat corpus cavernosum with neck bladder obstruction and given alpha blocker
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| Author:
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HUTASOIT CHARLES MARTAMBA, ANDI WARDIHAN SINRANG, MOCHAMMAD HATTA, HULDANI, FAUZIAH, BAYU INDRA SUKMANA, HARUN ACHMAD
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| Abstract:
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We conducted a review of evaluation erection function by assessing the expression level of nitrate oxidase in rats with neck bladder obstruction and got alpha blocker treatment. Abnormal condition of erectile dysfunction marked byitheiinability toihaveianierectioniorimaintainiiian erectioniduringiintercourse. Many factors can cause this condition. One of them is due to the low synthesis of nitric oxide. Because nitric oxide is the main mediator during erection process. Thus, nitric oxide values and erectile function are considered to have a direct relationship. While alpha blockers or alpha adrenoceptor antagonistsiplayiiiiaiiirole niiithe contractioniofismoothimuscleiifrom several urinary tract organs, such as the prostate and bladder. In the case of urinary tract obstruction, alpha blockers are used as treatment. The presence of a blockade inithese receptorsiwili causeirelaxationiofithe bladderineckismoothimusclesiiiand smooth the urine flow. The uses of alpha blockers can improve erectile function. However, not all study results showes the significant differences in nitric oxide expression between before and after alpha blocker use. This may be influenced by many factors, including the type and dose of alpha blockers used.
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| Keyword:
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Erectile function, Nitric oxidase, Bladder neck obstruction, Alpha blocker
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.140
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