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Synthesis, Characterization and Cytotoxicity Activity Study of Some Indole Schiff Base derivatives
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| Author:
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DALYA ABDULSATTAR JAMEEL, FADHIL LAFTA FARAJ, WASSAN BAQIR ALI
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| Abstract:
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Series of new indole based Schiff base derivatives were designed and synthesized by reacting 2-(1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene) malonaldehyde with different substituted aniline. The chemical structure of the compounds were confirmed and characterized by spectroscopic techniques (FT-IR, 1H-NMR and APT 13C-NMR). The target compounds with different concentrations were screened for their cytotoxicity activity against AMJ-13 breast cancer cell line. The results showed that compounds have promising cytotoxicity activity against AMJ13 cell line particularly compound (3) showed highest inhibition at 100 µg/ml rate among the tested compounds with variety concentrations .
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| Keyword:
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Schiff bases, indole derivatives, cytotoxicity activity, substituted anilines
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.118
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| Download:
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