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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Study of some Physiological and Biochemical parameters in female offspring born from dams treated with Dexamethasone during lactation period

Author: ADEL M. HASSEN, MOHAMMED ABDULHAMEED YOUNIS, JASSIM M. A. ALKALBY
Abstract: The present study amid to investigate the effect of dexamethasone on some hematological and biochemical parameters on offspring from dams rats treated during lactation ,therefore we used twelfth male rats mated with twenty four adult female .The rats divided into three equal groups ,group one control the female rats treated normal saline , group two the dams treated during lactation S.C dexamethasone 150 mg/kg.BW for ten days ,group three the dams treated during lactation S.C dexamethasone 150 mg/kg.BW for thirty days . After that the offspring scarified and measured the hematological and biochemical .The results showed that RBC. Hb, PCV, MCH, MCV and MCHV did not reach a significant while WBC and lymphocyte appeared decreased ,granulocyte increased .The AST ,ALT and ALP showed increased significantly ,TC and TG appeared increased while LDL showed decreased significantly .
Keyword: Dexamethasone, Rats, lactation
DOI: https://doi.org/10.31838/ijpr/2020.SP1.122
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