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The Effect of Cigarette Smoke Exposure due to Placental Apoptosis and Gestation Outcomes at Gestation Disorders Mechanism In White Rat (Rattus norvegicus)
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| Author:
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PORTIA SUMARSONO, YENI DHAMAYANTI, GRACIA ANGELINA HENDARTI, WIDJIATI, EPY MUHAMMAD LUQMAN
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| Abstract:
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The aims of this research to find out the increased incidence of placental apoptosis, abnormal gestation outcomes, and to prove the emergence congenital defects in white rats were exposed to cigarette smoke during gestation. Female white rat (Rattus norvegicus) weighing between 200 and 250 g were used and superovulation used PMSG with a dosage of 10 IU/rat and HCG 10 IU/rat. Female rat were mated, the gestation was indicated by the visible mating plug covering the vulva and then the day was considered the first day of gestation. The animals of the smoking group were exposed to the smoke of five cigarettes per day, from the 6th to the 17th day of pregnancy. The conclusion of this research was the exposure of cigarette smoke can increase the occurence of placental apoptosis on the gestation disorder mechanism on white rat also proved that can cause external congenital disorder on white rat such as body weight loss, foetus body length loss, increasing occurrence of abortus.
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| Keyword:
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Cigarette smoke, placental apoptosis, congenital disorder.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.114
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| Download:
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