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The role of interleukin-23 overexpression in preterm labour
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| Author:
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ALAA MOHAMMED SADIQ,, LUMA S. ZEINY, MBCHB, DGO, FICOG, SHAMIM RIADH MOHAMMED AL AASAM, MBCHB, DGO, FICOG, ALAA JUMAAH MNAJI NASRAWI, MBCHB, F.I.C.M, NOOR ALI LAFTA, MBCHB, DGO
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| Abstract:
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Background: Cytokines may have a role in preterm labour pathophysiology. Many studies revealed the association of cytokines with preterm labour and explained partially the mechanism of preterm uterine contractions. Interleukin-23 (IL-23) is a novel pro-inflammatory cytokine that has been studied in many inflammatory and immunological conditions. The role of IL-23 overexpression in preterm labour is hypothesized by the causal link between inflammation and spontaneous preterm labour.
Objective: The study aimed to investigate the role of IL-23 in patients with preterm labour.
Study design: Case-control study.
Setting: AL-Zahraa Teaching for Maternity and Pediatrics in Al-Najaf city/Iraq.
Patient and methods: Fifty pregnant women in preterm labour with gestational age between 24 weeks to 36 weeks+6 days were controlled with fifty age- and gestational age-matched healthy pregnant women who were not in labour. The serum level of IL-23 was measured using the ELISA method and compared between the two groups.
Result: There is a significant difference (P<0.001) in the mean serum level of IL-23 between patients with preterm labour (27.39±12.04 pg/ml) and those healthy preterm pregnant women who were not in labour (11.05±4.39 pg/ml). Using a cut-off value of 13.15 pg/ ml for IL-23, the specificity, sensitivity, positive & negative predictive value and accuracy for the diagnosis of preterm labour were 92%, 90%, 90.2%, 91.8% and 91% respectively.
Conclusion: IL-23 is an excellent test with promising diagnostic value in patients with preterm labour.
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| Keyword:
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Cytokines. Preterm labour. Pregnancy. Interleukin-23.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.111
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| Download:
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