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An Overview on Acne Vulgaris
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| Author:
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AHSWANI KUMAR SINGH, PRAMOD KUMAR SHARMA2, NIRANJAN KAUSHIK
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| Abstract:
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The acne disease is a disorder of pilosebaceous units and highly common which is chronic and recurring and is distinguished due to the development of comedones (open and closed) and papules along with the formation of pustules, nodules, and cysts. Acne afflicts adolescent population mostly and adults occasionally with 9.4% global prevalence. The pathogenesis is multifaceted which involves increased androgen production (hyperseborrhea) followed by pilosebaceous unit hyperkeratinization, colonization of Propionibacterium acnes, along with releasing the inflammatory mediators. The key hormones such as androgens, insulin, insulin-like growth factor are responsible for the acne vulgaris progression and contiguous with various mostly preventable and modifiable risk factors, such as environmental factors, genetic predisposition, lifestyle factors and drug use by a successful management. Due to the exceptional patient prerequisites and its complex clinical presentation acne possesses various treatment challenges. There are various treatment options available, but the available guidelines are insufficient to make evidence-based recommendations. The treatment includes topical therapy such as benzoyl peroxide, antibiotics and retinoids, systemic retinoid and antibiotics, hormonal, and various adjuvant treatment modalities like comedo removal, laser, and light therapy intralesional injections and chemical peels. The present review focuses on a general overview of acne vulgaris and its treatment modalities available presently.
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| Keyword:
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Acne Vulgaris, Propionibacterium Acnes, Androgen Production, Inflammatory Mediators, Insulin-like Growth factor-1 (IGF-1), Pilosebaceous Unit, Topical Treatment, Systemic Treatment, Adjuvant Treatment, Laser Treatment, Light Treatment.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.051
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| Download:
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