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Synthesis, Characterization and Biological Evaluation of Thiazolidine-2,4-dione Derivative
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| Author:
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SHIVKANT PATEL, ASHIM KUMAR SEN, DILLIP KUMAR DASH, AVINASH KUMAR SETH, PIYUSHKUMAR SADHU
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| Abstract:
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Glitazone are known to exhibit antihyperglycemic activity by decreasing peripheral insulin resistance. Glitazone are agonists for the peroxisome proliferator-activated receptor, PPAR?, which regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. Several new insulin sensitizers are currently under investigation. Some of these belong to the Glitazone class, but others have different chemical structures in the present study, we have designed some novel glitazones based on the structure–activity relationships as possible PPAR? Agonists. The manually designed Thiazolidine-2,4-Dione derivative were synthesized by using the appropriate synthetic schemes and screened for their in vitro antihyperglycemic activity by Sucrose loaded model (SLM) and Alloxan induced diabetic model (AIDM). Infrared (IR), proton (H) nuclear magnetic resonance was used to characterize the newly synthesized Thiazolidine-2,4-Dione derivative. Compound S-07 exhibit great antihyperglycemic activity So the consideration for the use of these compounds as lead material for the further development of antidiabetic agents is encouraged.
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| Keyword:
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Thiazolidine-2,4-Dione, PPAR ? agonists, Glitazone, antihyperglycemic activity, Diabetes mellitus
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.106
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| Download:
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