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Neuroprotective Effect of Coenzyme Q10 and Sitagliptin against Experimentally- Induced Diabetic Neuropathy
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| Author:
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RAJESH A. MAHESHWARI, RAMACHANDRAN BALARAMAN, ASHIM KUMAR SEN, DHANYA B. SEN
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| Abstract:
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With the increasing incidence of diabetes around the world it has become mandatory to carry our research on diabetes. With this aim a study was initiated to find out the effect of an antioxidant with combination of antidiabetic drug to mitigate the incidence of diabetic complication like neuropathy. In the present study, an antioxidant, coenzyme Q10 and antidiabetic drug, sitagliptin were used to investigate their effect in experimentally induced diabetic neuropathy. Therefore, neuropathy was induced by administering streptozotocin-nicotinamide in rats. In other sets of experiments, animals were treated with coenzyme Q10 alone, sitagliptin alone and their combination. Sciatica nerve function test such as paw withdrawal response, muscular grip strength, tail flick response and parameters of oxidative stress (MDA, SOD and GSH) were assessed along with histological study in all the aforementioned treated animals. Treatment with Co-Q10 and SITA protected nerve damage due to the administration of STZ-NA. The antioxidant effect of coenzyme Q10 along with antidiabetic effect of sitagliptin were responsible for mitigating the nerve damage as well as alteration of biomarkers of oxidative stress along with histopathological changes. It is concluded that concomitant administration of Co-Q10 and SITA showed a more neuroprotective as well as antioxidant effect then when it is administered alone.
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| Keyword:
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Diabetic neuropathy, Coenzyme Q10, Sitagliptin, Paw withdrawal response, Antioxidant
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP1.104
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| Download:
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