|
Synthesis, anti-microbial and anti-oxidant activity novel triazolo-quinazolines
|
|
| Author:
|
NILESH KHAIRNAR, MALLESHAPPA NOOLVI, AVINASH PATIL
|
| Abstract:
|
The synthesis of 3-[substituted-2,4 triazolyl]-2-phenithrazoline-4[3H]-one and the biological evaluation of them
as anti-microbial and antioxidant agents have been recorded in the present study in an attempt to classify new
groups of antifungal agents. In the series synths, antimicrobial potential against numerous bacteria, including
Staphylococcus aureus, Bacillus subtilis, was evaluated for aeruginosa-pseudomonas and fungi; candida albicans
and aspergillus niger, and chloramphenicol and amphoterin-B. Similarly, antioxidant function was also examined
in these compounds with DPPH monitoring. Of the nine synthesized compounds, 7e contained an active
compound against gramme positive (S. aureus) and gramme negative bacteria (P. vulgaris). Similarly, 7b (88,23
percent) and 7e (89,23 percent) showed strong anti-oxidant activity as opposed to standard ascorbic acid (94
percent)
|
| Keyword:
|
Synthesis; quinazolin-4[3H]-one; anti-microbial activity; anti-oxidant activity
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.SP3.118
|
| Download:
|
Request For Article
|
|
|