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A study of the relationship of protein antigens extracted from house flies (Musca domestica ) to allergy patients in Basra province , Iraq
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| Author:
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, HUDA KADHIM KAREEM, MUSHREQ MEZAAL HAMAD, DHIA K.KAREEM, ALAA TARIQ ABDULWAHID
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| Abstract:
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The spread of hypersensitivity disease worldwide is similar to that of any epidemic disease. The present study dealt with one of the most important human allergens source, which are common house flies (Musca domestica). The current study carried out in Basrah city on 96 healthy people (control) and 96 people with allergies, as they were divided in to two groups depending on gender and age. The present study revealed that there was no significant difference (P>0.05) of ELISA test between the two age groups of patients. However, the high rate of sensitivity (12.5%) was seen in age >45. In addition, the current study revealed that there was no significant difference (p>0.05) of ELISA test between males and females of patients. However, the higher rate of sensitivity (16.6%) was seen in male. Furthermore, the present study revealed that there was a significant difference (P<0.05) in the HLA alleles distribution between patients and controls according to age. The patients higher than 45 age showed higher frequency for the HLA- DQB1*0602 (31.25%) and HLA- DQB1*0604 (15.63%) alleles. The current study revealed that there was a significant difference (P<0.05) in the HLA alleles distribution between patients and controls according to sex. The female patients showed higher frequency (29.36%) for the HLA- DQB1*0602. However, the male patients revealed high frequency (14.29%) for HLA- DQB1*0604. The seropositive showed higher frequency for HLA-DQB1*0602 (37.5%) and HLA-DQB1*0604(25%) compared to frequency of HLA- DQB1*0602 (29.55%) and HLA- DQB1*0604 (12.5%) alleles in seronegative patients. In conclusion,
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| Keyword:
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Antigen, house flies, ELISA assay, IgE , HLA ?, PCR
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP3.115
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| Download:
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