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Relationship between Maternal Age and the Incidence of Down Syndrome
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| Author:
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, AUDYA TYAS REGITA, RISTI SAPTARINI PRIMARTI, ERISKA RIYANTI, HARUN ACHMAD
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| Abstract:
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Introduction: Down syndrome is the most common genetic disorder in the world caused by abnormalities in the chromosome. Genetic disorders can be caused by trisomy 21, translocation, and mosaic. Trisomy 21 is characterized by an excess number of the 21st chromosome due to the nondisjunction where 21st chromosome fails to separate from the homologous chromosome; the incidence reaches 95% of the total Down Syndrome incidences in the world. Down syndrome is a multifactorial disease, including maternal and paternal age, environment, radiations and chemicals. The most common factor that increases the risk of Down syndrome is the age of mother. Aim: The aim of this study was to determine the relationship of maternal age with the incidence of Down Syndrome in Karawang Regency. Method: Analytic observation method was used in this research with a case-control design. Data analysis was calculated using Chi-square test with p-value 35 years old have 9.815 times greater risk compared to mothers who give birth at =35. Conclusion: There is a significant relationship between maternal age and the incidence of Down syndrome in Karawang.
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| Keyword:
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Down syndrome, nondisjunction, maternal age at delivery.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP3.105
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| Download:
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