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Mechanism of Endogenous Oxalate Synthesis and Its Degradation by Probiotic Bacteria in Humans
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| Author:
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SUKHMINDERJIT KAUR, RAJINDER KAUR
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| Abstract:
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Oxalate in human body can enter exogenously through diet or can be synthesized in hepatocytes and erythrocytes as the metabolic end products of various mechanisms. Glyoxylate and glyoxal is the immediate precursor for oxalate synthesis in liver and erythrocytes respectively. Different metabolic pathways are involved in different organelles, which have been poorly understood. Because 85-90% of the oxalate pool in body is contributed by endogenous synthesis, insights into biochemical pathways for its synthesis are important to understand. Endogenous oxalate synthesis may be associated with many lethal pathophysiological conditions including hyperoxaluria and renal failure. Also, oxalate sensitivity in body is associated with altered gut microbiome and genetic disorders. Alternation of diet in order to decrease oxalate content in body is a less considered alternative, gastrointestinal microflora utilizing oxalate as the source of carbon has been seen as the better option to degrade oxalate in human body. It becomes important to understand the mechanism through which these bacteria are acting expecting it to be a better therapeutic option in future. This article explains the biochemical route of oxalate production in human body and mechanism outlining the efficacy of probiotic bacteria to degrade oxalate.
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| Keyword:
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Hyperoxaluria, microbiome, microflora, oxalate, oxalate sensitivity.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP3.019
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| Download:
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