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Anticancer Potential Of Aromatase Inhibitor Loaded Nlcs In Pa 1 Cells.
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| Author:
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DHAIRYSHEEL GHADGE, NAMDEO JADHAV*
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| Abstract:
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The goal of this research was to create nanostructured lipid carriers (NLCs) for a poorly water-soluble drug Anastrozole and analyse its release profile, as well as its in vitro cancer efficacy. NLCs filled with anastrozole were prepared with a solvent evaporation process. Effects of the concentration of lipids and surfactants on particulate scale, zeta potential, interlock performance, drug loading and polydispersion index were studied. The optimised batch showed a particle size of 281,9±5,8 nm, trapping performance of 79,62±3.47 and a potential of 29,3±1,83 mv of zeta. The morphology of the NLC was examined using a high resolution electron scanning microscope (HRSEM), an optimised batch showing a smooth surface spherical morphology under electron scanning microscope. The loaded NLCs were tested further for in vitro drug release optimised batch with extended releases, as 87.02 ±0.69 percent drug release was indicated by in vitro cytotoxicity research, cell morphology study, and D in vitra morphology of formed ANZ NLCs on PA 1 human ovarian cell lines. NLCs consisting of compritol 888 ATO and capryol are capable of capturing the poorly water-soluble drug Anastrozole and the device has a large ability to predict cancer, thus offering greater opportunities to administer Anastrozole parenterally to treat ovarian cancer.
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| Keyword:
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Anastrozole, nanostrucutred lipid carriers, cancer, parenteral, PA 1 cell activity, cell uptake, DAPI, ovarian cancer.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP3.001
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| Download:
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