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A Novel Pulsatile Drug Delivery Approach – A Laconic Review
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| Author:
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, NIZAR AWISH JASSEM, SAMER K. ALI
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| Abstract:
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According to the circadian rhythm of the body, a pulsatile drug delivery device PDDS is built and hence the drug release occurred after a lag time as a pulse completely and quickly. This delivery system delivers the drug at the right time at the right place of operation, and in the right volume, resulting in enhanced compliance and therapeutic effectiveness of the patient. This article was updated to focus on the various forms and the latest technologies used to produce such formulations. The target for PDDS was many diseases including asthma, peptic ulcer, certain cardiovascular issues, and arthritis. PDDS can be categorized into time-controlled TCS systems in which the release of the drugs is primarily controlled by the delivery system; stimulus-induced PDDS in which the stimulation much like the pH, temperature, or enzymes controls the release of the drug.
The other method is an externally configured device where external stimuli, such as magnetic, electrical influence, and ultrasound, program the drug release. The above release mechanism is accompanied by marketed technologies like PulsincapTM, Diffucaps, OROS, and Orbexa.
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| Keyword:
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Pulsatile dosage forms, lag time, chronotherapy
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.576
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| Download:
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Request For Article
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