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Autism. What does it mean and what are the reasons for its occurrence and conduct a study to compare children exposed to lead and not exposed and its effect on autism
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| Author:
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, ANGHAM TARIQ ALI
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| Abstract:
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Autism is a neurodevelopmental disorder which affects communication and social interaction of children. It is a heterogeneous disease with various clinical presentations. Some genes are involved in its pathogenesis. It has been suggested that environmental exposure too many toxic metal such as mercury and cadmium can increase the risk of autism in addition to other factors.
The aim of our study was to compare blood lead levels among autistic and non-autistic children. And to estimate if there is a relationship between lead exposure and the increased frequency of autism among children in thiqar population.
This retrospective study included 40 children (20 with autism and 20without autism) referred from the different thiqar cities to the poisoning consultation center in thiqar. Data collection including age, gender, residence, referral source, and blood lead levels was taken from their medical records
The data was analyzed by using unpaired t test., with level of significance of less than 0.05 and The results of our study showed a high statistically significant difference in lead level that found between autistic and non-autistic children (38.414.±6.56µg/dl in autism group versus 4.631±0.563µg/dl in non-autism group) with a P value of less than 0.001.
Mean blood lead level was high in all participants, compared to the international values, which might indicate a high level of lead exposure in thiqar children due to environmental pollution. Autistic children have higher lead levels than non-autistic ones and this might explain the role of lead in the etiology of autism
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| Keyword:
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Autism, neurodevelopmental, international, social interaction, disease, genes.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.566
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| Download:
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