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Association Tap1 and Tap2 gene polymorphisms with Echinococcosis in Man and Camels (Camelus dromedaries).
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| Author:
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, AHMED E.G, GHAIDAA A.J
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| Abstract:
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Transport antigen-presenting (TAP) is located within (MHC) region of class II, TAP plays an important role in antigen presentation. The main objective of the study is to determine the possible association of TAP1 and TAP2 gene polymorphisms and the risk of cystic echinococcosis (CE) by screened the TAP1 and TAP2 in the Iraqi population and camels. In human, our results showed the genotype AG increased risk of cystic echinococcosis in patient group for TAP1
while genotype of GG without significant between them when the compared between the patient and control for TAP1 and TAP2 (p>0.05).
Regarding TAP2 the findings showed genotype of AG without significant (p>0.05) while the genotype AA as resistance factor. The results also indicated alleles contributed as a risk factor and this is evident in the G allele or resistance factor in allele A, in both genes (TAP1, TAP2). With respect to camels (Camelus dromedaries), the results showed TAP2 polymorphisms were determined only in infected with echinococcosis when compared healthy camel. Our results suggested an association of TAP2 polymorphism with CE through identifying five SNPs polymorphism which is found only in the infected samples with echinococcosis that was identified as follows (G>T (48), G>C (46), A>G (115), A>G (175) and A>G (509). In conclusion TAP genes polymorphism are involved in susceptibility to echinococcosis in a group of Iraqi patients studied and the camels, therefore this genetic variation can be a diagnostic and confirmatory tool for the diagnosis of echinococcosis.
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| Keyword:
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Tap1; Tap2; polymorphisms; Echinococcosis; Man; Camels.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.565
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| Download:
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