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Development And Validation Of Hplc Method For Determination Of Clotrin Ear Drop
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| Author:
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, ANKITA KASABE, ARCHANA YADAV, VIKRAM VEER, AMIT KASABE, SANTOSH FATTEPUR, NAGARAJA SREEHARSHA
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| Abstract:
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The study aimed to validate the Clotrin ear drop analytical method using modified wavelength using HPLC. A reliable and straightforward high-performance liquid chromatography method was used to confirm an ear drop in clotrin. Chromatography was performed on column C18 phenomena (4.6 * 250 mm * 5 mm) using mobile phase acetonitrile and diammonium hydrogen phosphate (buffer) (60:40 ). As a mobile process with a 1 ml/min flow rate, the detection was conducted at 210 nm, resulting in more reliable ear drop impurities. The statistical n analysis proves that the method for analyzing clotrimazole and lignocaine HCl in-ear drop is repeatable, sensitive, and more precise.
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| Keyword:
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Clotrimazole IP, lignocaine, clotrin ear drop, antifungal eardrop, method validation.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.550
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| Download:
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