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An Integrated Approach to Assessing the Diagnostic Significance of a Set of Markers in The Alzheimer's Disease Development with Early and Late Onset in The Kazakh Population
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| Author:
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, ALMAGUL A.NAGIMTAEVA, VALERY V.BENBERIN, TAMARA A.VOSHENKOVA, ANNA V.BOROVIKOVA, AINUR S.SIBAGATOVA
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| Abstract:
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Study purpose: To identify socio-demographic and clinical factors, describe and compare cognitive and biochemical outcomes and establish whether they are reliable biomarkers in patients with early onset of Alzheimer's disease and late-onset of Alzheimer's disease in the Kazakh population.
Materials and methods. A total of 349 patients with early onset of Alzheimer's disease (<65 years: n = 53 (15%) and late-onset of Alzheimer's disease (=65 years: n = 296 (86%)) were examined. cognitive functions.
Results. Patients in the early onset of Alzheimer's disease population showed high educational attainment and greater cognitive ability. Factors such as smoking and drinking did not differ between the early onset of Alzheimer's disease and late-onset of Alzheimer's disease groups. In terms of lifestyle data, rates of inactivity and excess nutrition were significantly higher in the late onset of Alzheimer's disease cohort compared to the early onset of Alzheimer's disease. Also, the early loss of a spouse or living alone is a significant risk factor in older age. When analyzing the association of MBI, arterial hypertension, and diabetes mellitus in the group of patients under 65 years of age compared with late Alzheimer's disease, a statistically significant association was found for BMI and arterial hypertension. There was no significant difference in the presence of diabetes mellitus between the early onset of Alzheimer's disease and late-onset of Alzheimer's disease. Laboratory values for C-reactive protein, triglycerides were significantly higher in the late onset of Alzheimer's disease population. The differences in studies of blood glucose, lipids, and creatinine levels were not significant.
Results. Alzheimer's disease in the Kazakh population, especially over 65 years of age, can be considered as a manifestation in the brain of a systemic complex metabolic disorder associated with age, which has common features and pathogenic pathways with diabetes mellitus, obesity, and atherosclerosis.
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| Keyword:
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Alzheimer's disease; early onset of Alzheimer's disease; and late-onset of Alzheimer's disease; cognitive impairment; dementia.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.541
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| Download:
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