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Metabolic Vulnerability Assessment in the Development of Parkinson's disease with early and late-onset in The Kazakh Population
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| Author:
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, ALMAGUL A.NAGIMTAEVA, VALERY V.BENBERIN, TAMARA A.VOSHENKOVA, ANNA V.BOROVIKOVA, ZHANNA M.ZHABAKOVA
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| Abstract:
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Study purpose: to determine the difference in socio-demographic and clinical - metabolic factors between the early onset of Parkinson's disease and late-onset of Parkinson's disease in the Kazakh population.
Materials and methods. We examined 52 patients with early onset of Parkinson's disease (<60 years: n = 53 (35%) and late-onset of Parkinson's disease (=60 years: n = 93 (64.2%)). All study participants were assessed for demographic, anthropometric and biochemical parameters).
Results. The average age was 52.38 ± 10.15 and 68.90 ± 10.72 years, respectively, for patients with early onset of Parkinson's disease and late-onset of Parkinson's disease. A higher proportion of women was similar in both groups, accounting for approximately 60% of the total number of patients with Parkinson's disease. No significant differences were found between the early onset of Parkinson's disease and late-onset of Parkinson's disease in the household population.
Factors such as smoking and drinking did not differ between the early onset of Parkinson's disease and late-onset of Parkinson's disease groups. In terms of lifestyle data, rates of inactivity and overnutrition were higher in the late onset of Parkinson's disease cohort compared to the early onset of Parkinson's disease. When analyzing the association of body mass index, arterial hypertension, and diabetes mellitus in the group of patients under 60 years old compared with late Parkinson's disease, no statistically significant relationship was found. Laboratory creatinine levels were slightly higher in the late onset of Parkinson's disease population. The differences in glucose, lipid, and blood levels were not significant. The average number of erythrocytes and lymphocytes, as well as the ratio of lymphocytes and erythrocytes, was lower in the early onset of Parkinson's disease compared to late-onset of Parkinson's disease (7.65 ± 0.85) and (4.98 ± 0.73), (29, 74 ± 0.96) and (26.84 ± 1.10), (4.35 ± 0.75) and (5.83 ± 0.59), respectively. The ratio of neutrophils to erythrocyte lymphocytes was also negatively associated with the early onset of Parkinson's disease (p <0.04).
Conclusion. Parkinson's disease in the Kazakh population, especially over 60 years old, can be considered as a manifestation in the brain of a systemic complex metabolic disorder and a peripheral immune disorder associated with age.
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| Keyword:
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Parkinson's disease; early and late-onset of Parkinson's disease; dementia; metabolic syndrome.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.540
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| Download:
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