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Formulation development and evaluation of sustained release tablet containing tamoxifen citrate and ibuprofen in treatment of metastatic breast cancer.
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| Author:
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SHRUTI SONAWANE, SANTOSH FATTEPUR, VINAYAK MADANE, AMIT KASABE, NAGARAJA SREEHARSHA
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| Abstract:
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Cancer is a group of diseases which include an abnormal increase in cell count, which may invade or spread into other parts of the body. One of the hallmarks of cancer is metastasis, which separates it from benign tumours. In case of breast cancer it may metastasize anywhere in the body. In the metastasis of breast cancer, inflammation or swelling with cancer cell generation can occur. In the present research, sustained release tablet containing tamoxifen citrate and ibuprofen is formulated which can be used in the treatment of metastasis of breast cancer. Tamoxifen citrate is an estrogen-blocker with potent antiestrogenic properties and Ibuprofen is a NSAID with antipyretic and analgesic effects being an inhibitor of cyclooxygenase. The combination tablet of Tamoxifen citrate and Ibuprofen with different HPMC grade polymers such as K35 M, E4 M and E10 M were formulated. The pre-formulation studies such as rest angle, bulk density, tapped density; the Hausner ratio and the Carr index were found to be within the normal limit. The absence of possible chemical reactions between the drug and polymers was suggested by FTIR spectra. Powder mixtures were compressed into tablets for weight variation, thickness, stiffness, friability and drug content evaluation after compression. The in vitro release of medicines was investigated for 12 hours with USP Type-II dissolution apparatus. Results showed that the drug release was maintained over 12 hours by formulations containing various polymers.
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| Keyword:
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Tamoxifen citrate, ibuprofen, sustained release, metastatic breast cancer.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.538
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| Download:
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