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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Mucormycosis osteomyelitis of the maxilla - a case series

Author: SHIVANGI GAUR, MADHULAXMI M, MUTHUSEKHAR. M. R, PROF. DR SENTHILNATHAN
Abstract: Due to its rich vascularity maxilla rarely undergoes necrosis but the presence of certain bacterial infections like osteomyelitis, viral infections like herpes zoster and fungal infections like mucormycosis or aspergillosis, increases its susceptibility to necrose. Mucormycosis also known as phycomycosis or zygomycosis is an acute opportunistic fulminant infection caused by a fungus from the Zygomycetes class of fungi. Mode of infection is inhalation of fungal spores, beginning in the nose and paranasal sinuses and subsequently invading surrounding vascular tissues leading to avascular necrosis of hard and soft tissues. Although mucormycotic osteomyelitis of the maxillofacial skeleton is now a rare entity with the advent of the antibiotic era, it still remains one of the most resilient infections to treat with considerable morbidity and burden on the healthcare system. As mucormycotic osteomyelitis has a heterogeneous pathophysiology, varied symptomatology, mode of clinical presentation and multitude of treatment modalities it holds a special interest amongst clinicians. We report two cases of maxillary mucromycotic osteomyelitis in patients one with controlled and one with uncontrolled diabetes mellitus to emphasise on early diagnosis and prompt treatment, thereby reducing the morbidity and mortality associated with this lethal fungal disease.
Keyword: Maxilla; Mucormycosis; Zygomycosis; Phycomycosis; Osteomyelitis; Necrosis; Uncontrolled Diabetes Mellitus
DOI: https://doi.org/10.31838/ijpr/2020.SP2.528
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