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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Detemination of Copper, Lead, Cobalt, Zinc and its effect on Glutathione and Superoxide dismutase enzyme in Cleaners in Thi-Qar Province, Iraq

Author: HAYDER ABDUL ABBAS, AFRAH ABD MAKTOOF
Abstract: This study was designed to measure the concentration of some Trace metals ( Copper, Lead, Cobalt & Zinc ) in the blood of its effect upon antioxidant enzymes ( Super oxide dismutase Enzyme and Glutathione ) parameters of cleaner workers in hospitals , have chosen three hospitals (Al- Hussein teaching hospital, Bant Al-Huda hospital and Al-Haboubi hospital ) in Al-Nasiriyah city (Center of Thi-Qar province southern of Iraq). The current study included 100 blood samples have collected randomly, 75 of it were taken from a group of cleaner workers at three hospitals. They aged from 20 to 55 years (them duration work was 1-33 years) and 25 samples of non- working as a control group, each sample of blood separate the serum for the purpose of divided into two parts, the first part to estimate of SOD enzyme & Glutathione, second part measuring the concentration of trace metals (lead, copper, Cobalt Zinc). Glutathione concentrations in age = 20 years ranged less than from age 1-9 year group for SOD enzyme concentrations in age = 20 years ranged less than from age 1-9 year group. increased significantly in hospitals workers within 1-9-year, with significant differences compared to other study groups. Also, the current study showed that the smoker workers were exposed to high concentrations of studied trace elements, but they had low concentrations of glutathione and SOD. However, the control group exposed to less concentrations of studied elements and they had high concentrations of enzymes.
Keyword: Copper; Lead; Cobalt; Zinc; Glutathione; Superoxide dismutase Cleaners; Thi-Qar
DOI: https://doi.org/10.31838/ijpr/2020.SP2.506
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