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Preparation and Evaluation of Phytosomal Gel of Cassia fistula Extract
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| Author:
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SHAILESH SHARMA, DAISY SHARMA
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| Abstract:
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The latest research aimed at formulating and analysing phytosomal gel. Phytosomal gel carbopol 940 is used as a gelling agent and by modified thin film hydration technique the phytosomes of Cassia fistula extract incorporated in the gel were made. Further gel was analysed using standard methods with various physical-chemical parameters such as pH, viscosity, and spreadability. In vitro release tests were also conducted on all formulations, and later 45 days stability trials were performed on the optimised formulation in order to see any improvements in the characteristics of the prepared phytosomal gel. All the formulations were tested by different parameters such as pH, propagation, viscosity, extrudability and the results were promising. Furthermore, in vitro release tests have been performed of all of the formulations, showing that the FP2 formulation is indeed the optimised formulation with the highest release of 92.51%. This was subject to stability tests for 45 days and at the end of the study the findings were considered to be acceptable and satisfactory. It can be inferred from the analysis that the prepared phytosomal gel was found to be secure and most promising carrier for plant extracts and that phytosomal gel is more convenient compared with the single plant extract gel in respect of the releasing pattern.
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| Keyword:
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Phytosomes, gel, stability, Herbs, Plant extract.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.497
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| Download:
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