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Antibacterial Activity of Sulfathiazole Schiff Bases ß-Cyclodextrin Inclusion Complexes
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| Author:
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JABBAR S.HADI, RAWAA M.O.HRAISHAWI, RAWAA M.O.HRAISHAWI, AQEEL T.KADUM, ABDULELAH A.ALMAYAHI
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| Abstract:
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One of oligosaccharides are Cyclodextrins with an outer surface hydrophilic and its central cavity is lipophilic, the size of ß- Cyclodextrins complexes with many drugs as well as the small organic molecules in a host-guest system where the guest interact with the Cyclodextrins lipophilic cavity via a physical interaction. Material and Methods: Inclusion complex between Schiff bases derived from sulfathiazole Schiff bases as a guest and ß-cyclodextrin as a host were prepared by freeze drying method .The mode of interaction between guest and host were characterized by IR, HNMR, 13CNMR and XRD. Particle size distribution of Schiff base and their inclusion complexes were compared to investigate the effect of complexation on particle size and surface area . Biological activity of Schiff bases and their complexes were estimated Escherichia coli, Pseudomonas aerogenosa and Staphylococcus aureus exerted antimicrobial susceptibility according to sulfa derivatives Concentrations and diffusibility potential. Results: E. coli had dramatically sensitivity than other bacteria like P. aerogenosa and S. aureus toward all prepared compounds that related hydrophobic and generation time of each bacterial species. Conclusion: sulfa and sulfa derivatives exerted high potential antibacterial activities against E. coli , P. aerogenosa and S. aureus.
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| Keyword:
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Sulfathiazole, Biological activity, ß-CD, PSD, Inclusion Complex.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.495
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| Download:
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