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Integrons, Classification, Types of Integron and Expression of Gene Cassettes: A review
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| Author:
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ANWAR A.ABDULLA
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| Abstract:
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Antimicrobial resistance had become a serious worldwide health problem. Antimicrobial resistance may result through several mechanisms that have been attributed to genetic mutation with low frequencies, and specific bacterial genes that have been associated with resistance against several antimicrobials used against host microorganisms. Transfer of the genes responsible for antimicrobial resistance horizontally is a central mechanism for the wide spread of the resistance among bacteria. This mechanism includes the transfer of transposons and plasmids that mediate antimicrobial resistance from one bacterium to others. Integrons are groups of genetic entities that can exchange combine, and lead to the expression of unique DNA elements that are called Gene cassettes. These cassettes contain a site-specific recombination mechanism. A particular bacterial genome portion, Integrons are considered to play an important role in transmission of antimicrobial resistance. . This review addresses how integrons and multidrug resistance spread among different bacteria.
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| Keyword:
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Gene cassettes; Integron; antibiotic resistance; HGT
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2. 494
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| Download:
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