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Article Detail
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The protective efficacy of parsley seed extracts on some physiological and biochemical criteria against cadmium induced toxicity
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| Author:
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HAIDER H.HUMAISH, AMER ALASADI, ZAHRAA Z.MUSLEM
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| Abstract:
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Cadmium is the most toxic environmental and industrial pollutant, which causes a harmful effect for both human and animals. The antioxidant properties of herbal plants may open a new avenue to treat or relief many chronic diseases like Diabetes Mellitus, cardiac diseases and several health problem associated with heavy metal toxicity. Our study designed to examine the protecting efficacy of parsley seed extract (Petroselinum crispum) against cadmium chloride (CdCl2) toxicity to different vital organs of the male rats. The antioxidant properties of herbal plants may open a new avenue to treat or relief many chronic diseases like Diabetes Mellitus, cardiac diseases and several health problem associated with heavy metal toxicity. Forty Wister male rats divided into (4) equal groups: group1 was a negative control (drinking normal saline only), group (2) was treated with CdCl2 (200 mg /L water) and it was consider as positive control, group (3): rats given parsley extract daily at dose (500 mg /kg bw) orally as well as CdCl2 (200mg/L water), and group (4) rats were given parsley extract daily at dose (500 mg /kg bw) alone for 60 day. We evaluated the Total Cholesterol (TC), Triglyceride (Tg), Low -density lipoprotein cholesterol (LDL-C), Very density lipoprotein cholesterol (VLDL-C), High density lipoprotein cholesterol (HDL-C), liver function assays (Alanine aminotransferase (ALT), and Aspartate aminotransferase (AST), Alkaline Phosphate (ALP) and the bilirubin concentrations. In addition, we measured the antioxidant markers like (reduced glutathione concentration (GSH), Superoxide dismutase (SOD), Malondialdehyde (MDA) and Peroxy nitrate radical) concentrations for all treated groups. Our results showed the cadmium treated-rats alone-developed a liver injury represented by significant increased in lipid profile (TC, TG, LDL-C and VLDL-C levels) with clear decreased in HDL-C level. Moreover, antioxidant and lipid peroxidation markers (GSH, SOD, MDA, and Peroxy nitrate radical) significantly reduced in-group (2) compared with group (1). In addition, the serum liver biomarkers (ALT,AST,ALP, and bilirubin) were elevated with clear declined in albumin concentration in-group 2. Furthermore, our results showed that parsley seed extract plus CdCl2 group showed a significant improvement in all parameters mentioned above compared to group2. Additionally, the histopathological section of liver in parsley treated-rats showed a dramatic improvement in hepatic morphology and disappearance of signs of CdCl2 toxicity like degeneration of hepatocytes with necrosis, inflammation, and cytological vacuolization. Our results concluded that the parsley extract has a potent an antioxidant and protective roles against the toxicity cadmium chloride.
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| Keyword:
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parsley extract, antioxidant, cadmium toxicity, and lipid profile.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.492
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| Download:
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