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Synthesis, Characterization and Biological Activity of New Compounds Derived from Dapsone
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| Author:
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ZIAD T.I.ALKAYAR, WASEELA ABDUL REDAH ABDUL RAZAK, NAWAR JAMAL ABDULRADA, TAREQ K.IBRAHEEM
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| Abstract:
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New derivatives of the anti-inflammatory, leprostatic drug dapsone 4 are synthesized, characterized and biologically screened by the treating the drug dapsone with chloroacetyl chloride in the presence of base. Both amino groups are acylated to give compound 6. The symmetrical acylated product then treated with Phenol, N-Acetyl-p-aminophenol, p-Chlorophenol, m-Chlorophenol, o-Hydroxybezoic acid and m-Hydroxybezoic acid to give compounds 8(a-f). The antimicrobial activity was tested for the synthesized compounds; activates were good compared to the parent drug. All the new compounds have scanned for their biological activities toward gram ?ve and gram +ve (M. tuberculosis, S. pneumoniae, E. coli and P. mirabilis) bacteria, the synthesized derivatives gave moderate to good activity toward both mentioned types of bacteria.
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| Keyword:
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dapsone, sulfones family, Antibacterial activity
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2. 489
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| Download:
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