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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Analytical method validation of rizatriptan benzoate in fasted state simulated intestinal fluid using UV spectrophotometric method

Author: KAVYA HR, SAYANI BHATTACHARYYA, RAGHAVENDRA REDDY HV
Abstract: Rizatriptan benzoate, a new antimigraine drug is a selective subtype agonist of serotonin 5-hydroxytryptamine receptor. The present study focuses on establishing an easy and quick UV spectrophotometric approach for the analytical estimation of the drug. The linearity, accuracy, precision, robustness and ruggedness of the process was developed as per International Conference of Harmonization (ICH Q2 R1) analytical validation guidelines. The study was carried out in Fasted state simulated intestinal fluid of pH 6.5 and ?max was found to be 280nm. The solution of pure drug was prepared in the dilution range of 10-60 µg/ml and the linear regression analysis showed good linear relationship with R value of 0.999. The sensitivity of the process was found to be robust. The %RSD was less than 2% and can be concluded that the developed process is simple, sensitive, robust, relatively inexpensive and suitable for analysis of commercial sample.
Keyword: Rizatriptan Benzoate, Antimigraine, Fasted state simulated intestinal fluid, UV Spectroscopy.
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