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Analytical method validation of rizatriptan benzoate in fasted state simulated intestinal fluid using UV spectrophotometric method
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| Author:
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KAVYA HR, SAYANI BHATTACHARYYA, RAGHAVENDRA REDDY HV
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| Abstract:
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Rizatriptan benzoate, a new antimigraine drug is a selective subtype agonist of serotonin 5-hydroxytryptamine
receptor. The present study focuses on establishing an easy and quick UV spectrophotometric approach for the
analytical estimation of the drug. The linearity, accuracy, precision, robustness and ruggedness of the process was
developed as per International Conference of Harmonization (ICH Q2 R1) analytical validation guidelines. The
study was carried out in Fasted state simulated intestinal fluid of pH 6.5 and ?max was found to be 280nm. The
solution of pure drug was prepared in the dilution range of 10-60 µg/ml and the linear regression analysis showed
good linear relationship with R
value of 0.999. The sensitivity of the process was found to be robust. The %RSD
was less than 2% and can be concluded that the developed process is simple, sensitive, robust, relatively
inexpensive and suitable for analysis of commercial sample.
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| Keyword:
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Rizatriptan Benzoate, Antimigraine, Fasted state simulated intestinal fluid, UV Spectroscopy.
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| EOI:
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| DOI:
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| Download:
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