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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of the therapeutic activity of Metformin in rabbits with nephropathy and brain histopathological changes induced by Doxorubicin.

Author: ZAHRAA AHMED OKHTI, RAGHAD ABDULMAHDI MOHSIN, AFRAH MOHAMMED HASSAN SALMAN, MOHAMMED HUSSEIN SHATY
Abstract: The aim of this study: To evaluate the protective activity of metformin from the toxic effect of doxorubicin by assess the histological alteration on both kidney and the cerebellum of the rabbits induced by doxorubicin. Methods: Four groups of adult male rabbits (twelve in total) were used in this study. A control group without doxorubicin/ metformin treatment, AD; a group of rabbits treated with 16 mg/kg of doxorubicin, CD; a group of rabbits treated with 4mg/kg twice a week for 14 days, CD +M; a group of rabbit treated with metformin (300 mg/kg per day) for two weeks, before 3 days of doxorubicin injection (4mg/kg twice a week for 14 days). Followed by a histopathological study of the organ tissues after sacrificed the anesthetic rabbits. Results: the treatment with a single dose of doxorubicin induced the infiltrating of macrophage and neutrophils around the renal tubules and glomerulei of the renal tissues. And in cerebellum, it’s showing degeneration of many purkinji cells, mononuclear cell infiltration. The symptom becomes sever in the animal group chronically induced by doxorubicin and the damage was extended to include the glomeruli represented by its atrophy, and in cerebellum it’s showing cystic vacuolation with myelin degeneration. However the last group showed acute cellular swelling degeneration with mononuclear cells infiltration, interestingly the absence of hyaline casts in the lumen of renal tubule. And in the brain, it shows mild neuroglial proliferation. Conclusion: the treatment with metformin is obviously reduced and mitigates the severe symptoms in both renal and brain tissues resultant from the chronic induction by the exposure to doxorubicin.
Keyword: Doxorubicin, metformin, nephropathy, cerebellum, histopathology
DOI: https://doi.org/10.31838/ijpr/2020.SP2.463
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