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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Evaluation of celastrus paniculatus for antiulcer activity in experimentally induced ulcers in rats

Author: ARINDAM DAS, DAS, JYOTHI Y, RADHIKA P, REMI LIZA GEORGE
Abstract: Celastrus paniculatus (Celastraceae) is a widely growing and cultivated traditional medicinal plant. An effort is made in this research to explore the antiulcer potential of the Celastrus paniculatus aqueous seed extract (CPAS) in ulcers in rats induced experimentally. CPAS was prepared by maceration using distilled water. Preliminary chemical tests of the extract were conducted using standard methods. The protective effect was investigated in ethanol, indomethacin and pyloric ligation induced ulcer models. The doses selected for the study were 200mg/kg and 400mg/kg. For all these gastric ulcer induced models of Ranitidine (50mg/kg) was used as a reference agent. The analyzed parameters were ulcer scores, free acidity (FA), total acidity (TA) and total protein (TP) to assess the gastroprotective effect. Preliminary chemical tests revealed that CPAS contains alkaloids, flavonoids, saponins, carbohydrates, steroids, glycosides and tannins. CPAS significantly inhibited ulcer scores, FA, TA and TP in all the different ulcer induced models compared to positive control group. The protection can be due to improvement of the gastric mucosal defensive factors in ethanol as well as in indomethacin induced ulcer model. From the outcomes obtained of the present study it is confirmed that CPAS possessing a significant anti-ulcer activity. Phytoconstituents like sterols, alkaloids, flavonoids, glycosides, tannins, saponins are already reported for their anti-ulcer activity. Some of the above mentioned phytoconstituents were identified with CPAS extract. Hence these can be accounted for the anti-ulcer activity.
Keyword: Peptic ulcer, Ranitidine, Celastrus paniculatus, ethanol, indomethacin, pylorus ligation.
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