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Instantaneous Determination of Paracetamol Aceclofenac Using Stability Indication and Atr-Ftir Assessment Techniques
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| Author:
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JAIGANESH S, AMRIN.S. A, DR ADITYA RAGHAVA GOLAKOTI, DR PSN RAJU
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| Abstract:
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An reduced entire reflectance-fourier transform infrared (ATR-FTIR) spectroscopy technique is established by simultaneous estimation of paracetamol and aceclofenac in Pharmaceutical tablets. The method involves the straight will power in the drug concluded peak measurement in the 3502 cm-1 for paracetamol and 1436 cm-1 for aceclofenacby means of a reference line improvement among 3800 then 1000 cm-1. For calibration an exterior standardization line recognized by average explanations of pure paracetamol and aceclofenac are utilized. The techniquedelivers a border of recognition for paracetamol is 9.18 and for aceclofenac is 7.95 for per mg tablet and Limit of Quantification for paracetamol is 27.84 and for aceclofenac is 24.11583for per mg tablet. The accuracy of the sample was found to be 0.816% for paracetamol and 1.32% for aceclofenac. A relative standard deviation (RSD) for 3 self-determining dimension of normal and test explanation at a attentiveness level of 1.5 mg/mL for paracetamol and aceclofenac is 0.000577%. Range for the tablet was 10µg/mL to 250 µg/mL for paracetamol and 10 µg/mL to 300 µg/mL for aceclofenac. The assay of the marketed tablet was found to be 149% and 142% for aceclofenac and paracetamol, the purity of the tablet was 65%. Result obtained by FTIR shows the established process and proposals a good alternate for the simultaneous willpower of paracetamol and aceclofenac in commercial products.
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| Keyword:
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Chemometrics, simultaneous determination, paracetamol, aceclofenac, ATR-FTIR, purity, validation.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.444
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| Download:
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