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Formulation and Evaluation of Ondansetron Hcl Soft Logenzes By Using Natural Sweetner
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| Author:
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PADMANABHAN P, PAUL T JOYES, DR. P. SUNIL KUMAR, DR. DHANWANTARI NAIDU
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| Abstract:
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In current survey, attempt was prepared to formulate the medicated lozenges of ondansetron hydrochloride. Ondansetron hydrochloride was used to treat chemotherapy induced nausea and vomiting. Although several formulations were available in the market, still there is requirement of further different dosage forms that performs more efficiently. The benefits of current work are to enhance oral bioavailability of drug by increasing retention time of dosage form. The lozenges were organized by congealing &heating technique by employing poly ethylene glycol 1500 as matrix base, stevia (natural sweetner), xanthan gum (polymer), sodium carboxy methyl cellulose (polymer), hydroxy propyl methyl cellulose K100M (polymer) along with other excipients. The prepared medicated lozenges are categorized for weight variation, drug content uniformity, friability, hardness, thickness, in-vitro dissolution &disintegration by pharmaceutical standard approaches. The accelerated stability surveys are conducted according to ICH rules; it was establish that there wasn’t any substantial communication between drug and excipients. Formulation was tested for drug excipient interaction by subjecting to IR spectral analysis.The accelerated stability surveys are carried out according ICH rules for few designated formulations that specified these formulations were constant at accelerated storage situations
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| Keyword:
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Lozenges, Ondansetron HCl, Antiemetic, Stevia, Chemotherapy, gastro-intestinal tract (GIT), radiation induced nausea and vomiting (RINV), post-operative nausea and vomiting (PONV), chemotherapy induced nausea and vomiting (CINV), lozenge formulations (LFs), calibration curve (CC), Drug Release Profile (DRP)
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.432
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| Download:
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