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A Pure Tablet for Stabilization Indication Of RP-HPLC Techniques by Estimating Pitavastatin And Ezetimible Solutions
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| Author:
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SRAVANATHI P, MUTHU BABU K, DR RAVIKUMAR RAJU, DR TEJA
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| Abstract:
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This paper proposes the Hyperlipidemia is one of the clinical conditions mainly associated with coronary heart disease. Use of Statins in combination with Ezetimibe proven to give better results in treatment of said conditions. The current work aims to progress a simple accurate and sensitive stability indicating technique for estimation of Pitavastatin and Ezetimibe in pharmaceutical dosage form.The separation was achieved by using X-Bridge Phenyl (150×3.5µ, 4.6mm) column with a mobile phase containing of 0.1% Formic acid and Methanol (30:70). The separation was monitored for 8min at 250nm using 1ml/min flow rate. The established technique authenticated as per ICH Q2 (R1) rules. The technique was linear over a absorption rangeof 1 to 15ppm and 5 to 75ppmfor Pitavastatin and Ezetimibe respectively and correlation coefficient isoriginate to be 0.999 for the drugs.HPLC technique developed for approximation of selected drugs in pure and have shown satisfactory, accurate and reproducible results (without any interference of recipients) as well, it is inferred that the modest and petite projected methods be greatest valuable for investigation resolution. The present work concluded that stability indicating assay method by RP-HPLC was simple, accurate, precise, and specific and has no interference with the placebo and degradation products. Hence these are utilized for regular examination of Pitavastatin and Ezetimibe.
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| Keyword:
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Hyperlipidemia, Pitavastatin, Ezetimibe, RP-HPLC, Stability Indicating
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.428
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| Download:
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