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Design, Synthesis and Preliminary Pharmacological Evaluation of Mutual Prodrug of Non Steroidal Anti-Inflammatory Drugs Coupling with Natural Anti-Oxidants
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| Author:
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AMMAR ABDUL AZIZ, SAMER A. HASAN, AHMAD K. HUSSEIN, NOOR H. NASSER, KARRAR ABDIL AZIZ ALIBEG
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| Abstract:
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Non steroidalanti inflammatory drugs NSAIDs Etodolac and tolmetin drugs have been coupled with varies natural antioxidants having antiulcerogenicpropertiesin order to get mutual prodrug consist of NSAIDs & antioxidant as a safer NSAIDs withoutgastrointestinal side-effects. The designated pro-drugs are well studied to explain their anti inflammatory, anti ulcer and analgesic activity. The mutual prodrug shows the same activity as anti inflammatory with decrease ulcerogenecity. The study results show that the mutual prodrug of NSAIDs antioxidant has the strength to create new NSAIDs with decreased undesirable adverse effects.
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| Keyword:
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Antioxidant, NSAIDs, Etodolac and Tolmetin, mutual prodrug, gastrointestinal ulceration.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.SP2.450
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| Download:
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