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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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DEVELOPMENT AND VALIDATION OF STABILITY INDICATING ASSAY METHOD FOR SIMULTANEOUS ESTIMATION OF EPERISONE HYDROCHLORIDE AND DICLOFENAC SODIUM IN BULK AND SOLID DOSAGE FORM

Author: RAM SAKHARE, SANJAY PEKAMWAR, KALYANI DANNAK
Abstract: The present work describes development of simple, accurate, rapid and precise Stability Indicating UV-Spectrophotometric method for simultaneous estimation of Eperisone hydrochloride (EPE) and Diclofenac sodium (DICLO) in bulk and capsule dosage form. The developed method was validated by using parameters like linearity, precision, accuracy, LOD and LOQ. The Beer’s law was obeyed in the concentration range of 3-18 µg/ml and 2-12 µg/ml for Eperisone Hydrochloride and Diclofenac sodium with a correlation coefficient (r2) 0.999 for both the drugs respectively. Recovery study values of Eperisone Hydrochloride and Diclofenac sodium were found to be 99.8% and 101.2% respectively. The % RSD for intra-day and inter-day precision studies was found less than 2. The LOD and LOQ were found to be 1.66 µg/ml and 5.04 µg/ml for Eperisone hydrochloride and 2.97 µg/ml and 9.025 µg/ml for Diclofenac sodium respectively. The developed method was successfully applied to estimate the amount of Eperisone hydrochloride and Diclofenac sodium in bulk and capsule dosage form.
Keyword: Eperisone hydrochloride (EPE), Diclofenac sodium (DICLO), Simultaneous Estimation, Validation, Stability Indicating, Forced degradation study
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