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FORMULATION, OPTIMIZATION AND EVALUTION OF SUSTAINED RELEASE MICROSPHERES OF REPAGLINIDE.
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| Author:
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NIRMAL VASHI
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| Abstract:
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The aim of the present study was to formulate and optimize microspheres of Repaglinide. Here, Repaglinide was incorporated in microsphere to sustain the release. Microspheres were prepared by Quasi-emulsion solvent diffusion method. On the base of trial batches two factors (Polymer Concentration (mg) X1 and Speed (RPM) X2) and their three levels were selected and a 32 full factorial design was applied. The dependent variables to be measured were Yield %, Particles size (µm), Entrapment Efficiency and % drug released. Evaluation of contour plots revealed that various factor affected various variables differently that is concentration of polymer had varying effect on % Yield, it was observed that as the concentration of polymer increases the yield increases. Which means that as the concentration of polymer increases the solubility of the polymer achieved saturation and therefore yield increased and the effect on particle size it was observed that both of our factors had oppose effect on our dependent variable that is as the concentration of polymer increased the particle size increased but as the stirring speed increased the particle size decreased, on the third variable that is Entrapment Efficiency, this variable was majorly dependant on polymer concentration as the concentration increased entrapment efficiency also increased, it had little effect of stirring speed on entrapment efficiency. The last variable was Cumulative Drug Release this variable was dependant on both our factors, as follows as the polymer ratio increased the release was sustained for a longer period of time and as the stirring speed increased the particle size decreased and hence the microspheres were unable to sustain the release of the drug
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| Keyword:
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Repaglinide, Microspheres, 32 factotial design, Contour plots
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| EOI:
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| DOI:
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