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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Inhibition of Calcium Oxalate Crystallization by the Fruit Extracts of Solanum xanthocarpum Schrad. & Wendl. and Pedalium murex Linn.

Author: UPLOADED BY-ADMIN, PARAS K.PATEL, NITESH NAYAK, HITESH PATEL, MANISH A. PATEL, MAHESH G. SARALAI, TEJAL R. GANDHI
Abstract: Urinary stones are one of the oldest and the most common afflictions in humans. This disease has tormented humans since the earliest records of civilization. Ten percent of men and 3 % of women have a stone during their adult lives. Calcium containing stones are the most common comprising about 75 % of all urinary calculi, which may be in the form of pure calcium oxalate (50 %) or calcium phosphate (5 %) or a mixture of both (45 %). A number of plants have been mentioned in the Indian ayurvedic system, which plays a vital role in the inhibition of kidney stones. In the present study, the inhibitory potency of alcoholic and aqueous extracts of SolanumxanthocarpumSchrad. &Wendl.andPedalium murex Linn. fruitswere evaluated on various stages of formation and on the growth of calcium oxalate crystals in vitro. A result obtained showed that alcoholic extract of both plants has the higher capacity to inhibit the crystal formation and aggregation as compared to their aqueous extracts. This effect may be because of the presence of saponin in the plant extract.
Keyword: Calcium oxalate, Pedalium murex, Solanumxanthocarpum, antiurolithiasis.
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