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Pharmaceutical and chromatographical evaluation of dental gel containing bioactive: catechin
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| Author:
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DR. SUPRIYA JIRGE, TEJASVI P. CHALKE , ABHISHEK. D. DORLE , KRISHNA R. SHARMA , SUJIT K. NAGARE
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| Abstract:
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The present study deals with formulation of bioactive extract of leaves of Anacardium occidentale (cashew) into a dental gel and its evaluation. Dried, powdered bark was extracted with ethanol for 18 hours in a soxhlet apparatus. Catechin is one of the main constituent of the polyphenol of cashew leaves and same was further extracted from ethanol extract. Five dental gels containing catechin rich extract were formulated using various gelling agents. These gels were evaluated for physicochemical parameters, viscosity, spreadibility, extract content, dissolution, mucoadhesion, toxicity, in vitro permeation studies and antimicrobial activity. The selected gel was obtained as a brownish red colored lustrous gel having pH between 7.3-7.5 with a good spreadibility of 4-5secs and mucoadhesive force of 0.1gm. The content of catechin in the gel was 101.25% w/w by HPTLC method. The gel showed significantly good antimicrobial activity to that of ethanol extract and catechin rich extract. In dissolution studies the extract is released completely within 4 hours. In in-vitro permeation studies the entire extract is released within 6 hours. A dental gel was successfully formulated containing catechin rich extract of leaves of Anacardium occidentale.
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| Keyword:
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Anacardium occidentale, Catechin, Cashew, Dental gel, HPTLC
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| EOI:
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| DOI:
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