|
Microwave- assisted one-pot synthesis of amino acid methyl ester hydrochlorides
|
|
| Author:
|
SUNEELA DHANESHWAR, AJINKYA SARKATE
|
| Abstract:
|
Methyl N-unprotected ?-amino acid esters are important intermediates in organic synthesis and can be conveniently prepared by a Fisher-type esterification. Microwave (MW)-assisted organic synthesis has evolved as an important technique in green chemistry and has shown high impact in enhancing the rates of reaction and speeding up library synthesis. It provides faster direct ‘in-core’ heating compared to conventional heating. This helps in accelerating the reaction rates, producing lesser byproducts, higher yields and simplified work-up. Present work reports a comparative account of conventional and MW-assisted synthesis of amino acid methyl esters. Esterification by conventional method required 7-8 h for completion with 62-86 % yields, while by MW technique the reaction was complete in merely 9-15 min with improved yields of 86-95 %. Thus, the reported MW technique contributes to the promotion of economical and environmentally friendly experimental procedure for synthesis of different amino acid methyl esters with reduced reaction time, simple and easy work-up, excellent yields and higher purity compared to the conventional methods.
|
| Keyword:
|
Amino acid methyl ester hydrochloride, Microwave (MW)-assisted synthesis, Conventional synthesis, Esterification
|
| EOI:
|
-
|
| DOI:
|
-
|
| Download:
|
Request For Article
|
|
|