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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Screening of Formulating and Processing Parameters on Candesartan Cilexetil Nanosuspension Prepared by Nanoprecipitation-Ultrasonication Technique.

Author: JALPA PAUN, HEMRAJ M. TANK
Abstract: Background: Low oral bioavailability of poorly water-soluble drugs poses a great challenge during drug development. Poor water solubility and low dissolution rate are issues for the majority of upcoming and existing biologically active compounds. Candesartan Cilexetil is BCS class-II drug having low solubility and high permeability. Aim and objective: The aim of the present investigation was to identify critical formulating and processing parameters which influences on quality of the nanosuspension. Method: Nanosuspension formulation of a poorly soluble drug was developed using nanoprecipitation-ultrasonication technique. Key factors affecting formulation of nanosuspension were identified by Plackett and Burman Design of experiments to optimize nanosuspension and evaluation was done by measurement of saturation solubility, mean particle size, poly dispersity index and zeta potential. Results: The obtained results showed that nanosuspension prepared with the PVPK-30 has improved saturation solubility as compare to all other stabilizers. Result also revealed that solvent: anti-solvent ratio (with coefficient 9.4525) as well as concentration of drug (with coefficient 9.0125) were found to be promising formulating parameters having prominent effect on quality of Candesartan Cilexetil nanosuspension.
Keyword: Candesartan Cilexetil, Nanosuspension, Nanoprecipitation-ultrasonication, Plackett and Burman design.
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