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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Importance of the Effect of MPEG on Wetted PEO in Extrusion-Spheronization of Beads

Author: UPLOADED BY-ADMIN, MATTHEW A. HOWARD, STEVEN H. NEAU
Abstract: An alternative approach to produce extruded-spheronized beads, devoid of microcrystalline cellulose and with a high drug load (greater than 80% w/w), was offered in an earlier publication. Herein, the formulation components, namely pseudoephedrine hydrochloride, polyethylene oxide and methoxypolyethylene glycol, were studied to investigate the function of the excipients and, in particular, to propose a mechanism for the anti-tack effect of methoxypolyethylene glycol on wetted polyethylene oxide. Extrusion-spheronization experiments were completed to directly evaluate the effect of the polyethylene oxide:methoxypolyethylene glycol mass ratio on selected characteristics of the beads. The effect of increasing polyethylene oxide, methoxypolyethylene glycol, and pseudoephedrine hydrochloride relative concentrations was evaluated in a force of detachment study using well hydrated samples. The results confirmed that wetted polyethylene oxide functions as a binder, increasing the force of detachment; changes in pseudoephedrine hydrochloride concentration produced a statistical effect that could not be discriminated from no effect at all; and the antitack effect of methoxypolyethylene glycol could not be enhanced above a certain level. Temperature modulated differential scanning calorimetry results helped establish that, up to a 2:1 polyethylene oxide:methoxypolyethylene glycol mass ratio, methoxypolyethylene glycol occupies water binding sites on the polyethylene oxide, which weakens the polyethylene oxide hydrogel. Above that 2:1 mass ratio, methoxypolyethylene glycol self-associates to form multiple layers on polyethylene oxide.
Keyword: extrusion, spheronization, polyethylene oxide, methoxypolyethylene glycol, force of detachment, differential scanning calorimetry
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