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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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RECENT APPLICATIONS OF HYBRID NANOBIOMATERIAL AS NON-VIRAL GENE DELIVERY VEHICLES

Author: KIRTI SHARMA
Abstract: Recently, newly proposed bionanomaterials e.g. such as metallo-conjugated or hybrid magneto, chitosan, glycanoparticles, albumin, liposome, quantum dots, conjugated nanoscaffolds and other fabricated polymers were formulated and proposed for their safe use as nonviral gene delivery vehicles due to exhibiting their novel characteristics such as non-toxicity, non-immunogenicity and biocompatibility. These prepared hybrid or conjugated bionanopaticles were also found to be effective and more potent nonviral gene/drug/nucleic acid/loaded biological or chemical components delivery vehicle at the targeted site that found suitable for cancer therapy, genetic vaccines, and stem cell engineering. These hybrid nanomaterials are known as chemically or biologically engineered nanomaterials that have dimension in the range of 1-100nm. These nanosized bioparticles were exhibited the high site-specific reactivity, greater sensing capability and increased mechanical strength which offered easy, safe, fast, efficient, and cost effective synthesis of these nanomaterials. These nanobiomaterials were also proposed as a promising therapeutic tools used for the treatment of genetic, metabolic and neurodegenerative disorders as more potent and safe nonviral delivery due to having non-immunogenicity, low toxicity, biocompatible and potential site specificity.
Keyword: Nanobiomaterials; Iron nanoparticles; Chitosan nanoparticles; Albumin nanoparticles; Nanoscaffold; Nonviral delivery vehicles
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0.12
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