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Quantitative Correlation Between NK Cell Activity in Tissue Sample with HCV-viral Load And Disease Activity
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| Author:
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ADIL SHUIB, AMEERDHAHIR HAMEEDI, HASSAN J. HASONY, SAFAA.ABUL RAZZAK
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| Abstract:
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Hepatitis C virus is a blood-borne virus transmitted by percutaneous exposure to infected blood or blood-derived
body fluids. The ability of HCV to establish persistent infection is partly due to its ability to evade the immune
response through multiple mechanisms, including suppression of NK cells. Natural killer (NK) cells serve as a first line
of defense against acute viral infections. This study tends to test the correlations between NK cell activity defined by
CD16 immunohisto chemical expression as their activation marker, serological viral load and histological activity
index (HAI) and fibrosis. Thirty-two cases with chronic viral hepatitis C were studied retrospectively in Iraq Using the
data regarding the age, gender and the serological viral load. Their liver needle biopsies were reviewed for the
histological activity stage of fibrosis. Then immunohisto chemical staining for CD16 was performed and the positively
stained lymphocytes in the portal tracts were counted taking the average number per each tract in each patient.
Statistical significant correlation was found between viral load and (fibrosis, HAI) (P=0.047, P=0.029), respectively.
There was no statistical significant correlation between number of CD16-positive NK cell in the portal area and
fibrosis, HAI, viral load and genotype. (P value >0.05). During HCV infection, severity of liver disease is correlate with
viral load. Intrahepatic NK cells activating receptor CD16 has no statistical significant correlation with necro
inflammation and fibrosis nor with viro logical parameters in the disease progression and chronicity. Their role might
be more important in the acute or sub-acute stage of disease.
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| Keyword:
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CD16, hepatitis C viral infection, Natural Killer cells
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2019.11.02.086
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| Download:
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