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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

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0975-2366
5 - Years Impact Factor

Year 2012 - 2016

Impact Factor: 1.55

Total Publications: 317

Total Citation: 491

Year 2011 - 2015

Impact Factor: 1.46

Total Publications: 326

Total Citation: 477

Year 2010 - 2014

Impact Factor: 1.3

Total Publications: 313

Total Citation: 407

Year 2009 - 2013

Impact Factor: 0.973

Total Publications: 293

Total Citation: 285

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Quantitative Correlation Between NK Cell Activity in Tissue Sample with HCV-viral Load And Disease Activity

Author: ADIL SHUIB, AMEERDHAHIR HAMEEDI, HASSAN J. HASONY, SAFAA.ABUL RAZZAK
Abstract: Hepatitis C virus is a blood-borne virus transmitted by percutaneous exposure to infected blood or blood-derived body fluids. The ability of HCV to establish persistent infection is partly due to its ability to evade the immune response through multiple mechanisms, including suppression of NK cells. Natural killer (NK) cells serve as a first line of defense against acute viral infections. This study tends to test the correlations between NK cell activity defined by CD16 immunohisto chemical expression as their activation marker, serological viral load and histological activity index (HAI) and fibrosis. Thirty-two cases with chronic viral hepatitis C were studied retrospectively in Iraq Using the data regarding the age, gender and the serological viral load. Their liver needle biopsies were reviewed for the histological activity stage of fibrosis. Then immunohisto chemical staining for CD16 was performed and the positively stained lymphocytes in the portal tracts were counted taking the average number per each tract in each patient. Statistical significant correlation was found between viral load and (fibrosis, HAI) (P=0.047, P=0.029), respectively. There was no statistical significant correlation between number of CD16-positive NK cell in the portal area and fibrosis, HAI, viral load and genotype. (P value >0.05). During HCV infection, severity of liver disease is correlate with viral load. Intrahepatic NK cells activating receptor CD16 has no statistical significant correlation with necro inflammation and fibrosis nor with viro logical parameters in the disease progression and chronicity. Their role might be more important in the acute or sub-acute stage of disease.
Keyword: CD16, hepatitis C viral infection, Natural Killer cells
DOI: https://doi.org/10.31838/ijpr/2019.11.02.086
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Impact Factor for five years is 1.55 (2012 - 2016)

Year 2011 - 2015 Impact Factor - 1.46 Total Publications - 326 Total Citations - 477